Nanoparticles have an extraordinarily large surface to volume ratio that leads to surface properties governing their colloidal properties and their general behavior. Due to this dependency, it is essential to ascertain the surface properties in the technical application of particles where adhesive surface effects play a role, such as in paint and ink manufacturing. The strength of electrostatic repulsive forces, a function of the Zeta potential, drives the stability of charged particles against agglomeration. Furthermore, Zeta potential measurements are applied to determine the isoelectric point of titration in water treatment. In biological applications, the Zeta potential is used to assess the applicability of a functional particle and to investigate the success of surface-modifying experiments.